Acyclovir is an antiviral agent with activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella zoster virus. Acyclovir is converted by a herpesvirus enzyme into acyclovir triphosphate that inhibits the synthesis of deoxyribonucleic acid (DNA) molecules in the virally infected cells, thereby inhibiting viral replication. It induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).
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Chemical |
CAS Num |
59277-89-3 |
Chemical Formula |
C8H11N5O3 |
Molecular Weight |
225.21 |
IUPAC Chemical Name |
2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one |
Exact Mass |
225.08619 |
Elemental Analysis |
C, 42.67; H, 4.92; N, 31.10; O, 21.31 |
Synonym |
Acyclovir; Acycloguanosine; Aciclovir; Zovirax; Vipral. |
Solubility |
Soluble in DMSO, not in water |
SMILES Code |
C1=NC2=C(N1COCCO)NC(=NC2=O)N |
Biological |
Targets and Effects |
HSV-1 and HSV-2 |
Pathways |
Apoptosis |
Physical |
Appearance |
Solid powder |
Purity |
>98% (or refer to the Certificate of Analysis) |
Shipping Condition |
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition |
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Shelf Life |
>2 years if stored properly |