Alpha-Mangostin, 95%
Alpha-Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities. α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell. Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity.
1: Lee J, Kang JS, Choi BY, Keum YS. Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin. Biomol Ther (Seoul). 2016 Nov 1;24(6):604-609. doi: 10.4062/biomolther.2016.028. PubMed PMID: 27469143.
2: Lee KW, Ryu HW, Oh SS, Park S, Madhi H, Yoo J, Park KH, Kim KD. Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy. Exp Dermatol. 2016 Oct 7. doi: 10.1111/exd.13233. [Epub ahead of print] PubMed PMID: 27714857.
3: Verma RK, Yu W, Shrivastava A, Shankar S, Srivastava RK. α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice. Sci Rep. 2016 Sep 14;6:32743. doi: 10.1038/srep32743. PubMed PMID: 27624879; PubMed Central PMCID: PMC5021984.
4: Guo M, Wang X, Lu X, Wang H, Brodelius PE. α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF. PLoS One. 2016 Sep 1;11(9):e0161566. doi: 10.1371/journal.pone.0161566. PubMed PMID: 27584012; PubMed Central PMCID: PMC5008840.
5: Phitaktim S, Chomnawang M, Sirichaiwetchakoon K, Dunkhunthod B, Hobbs G, Eumkeb G. Synergism and the mechanism of action of the combination of α-mangostin isolated from Garcinia mangostana L. and oxacillin against an oxacillin-resistant Staphylococcus saprophyticus. BMC Microbiol. 2016 Aug 26;16(1):195. doi: 10.1186/s12866-016-0814-4. PubMed PMID: 27566110; PubMed Central PMCID: PMC5002192.
6: Kwak HH, Kim IR, Kim HJ, Park BS, Yu SB. α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell. Evid Based Complement Alternat Med. 2016;2016:5352412. doi: 10.1155/2016/5352412. PubMed PMID: 27478478; PubMed Central PMCID: PMC4960343.
7: Nava Catorce M, Acero G, Pedraza-Chaverri J, Fragoso G, Govezensky T, Gevorkian G. Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. J Neuroimmunol. 2016 Aug 15;297:20-7. doi: 10.1016/j.jneuroim.2016.05.008. PubMed PMID: 27397072.
8: Kaomongkolgit R, Jamdee K. Inhibitory effect of alpha-mangostin on Candida biofilms. Odontology. 2016 Jul 1. [Epub ahead of print] PubMed PMID: 27368963.
9: Lee D, Choi YO, Kim KH, Chin YW, Namgung H, Yamabe N, Jung K. Protective effect of α-mangostin against iodixanol-induced apoptotic damage in LLC-PK1 cells. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3806-9. doi: 10.1016/j.bmcl.2016.05.031. PubMed PMID: 27293071.
10: Mekseepralard C, Areebambud C, Suksamrarn S, Jariyapongskul A. Effects of Long-Term Alpha-mangostin Supplementation on Hyperglycemia and Insulin Resistance in Type 2 Diabetic Rats Induced by High Fat Diet and Low Dose Streptozotocin. J Med Assoc Thai. 2015 Nov;98 Suppl 10:S23-30. PubMed PMID: 27276829.
11: Willson CM, Grundmann O. In vitro assays in natural products research - a matter of concentration and relevance to in vivo administration using resveratrol, α-mangostin/γ-mangostin and xanthohumol as examples. Nat Prod Res. 2016 May 27:1-15. [Epub ahead of print] PubMed PMID: 27234135.
12: Xia Y, Li Y, Westover KD, Sun J, Chen H, Zhang J, Fisher DE. Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin. PLoS One. 2016 May 6;11(5):e0155217. doi: 10.1371/journal.pone.0155217. PubMed PMID: 27152946; PubMed Central PMCID: PMC4859503.
13: Xia Y, Chen J, Gong C, Chen H, Sun J. α-Mangostin, a Natural Agent, Enhances the Response of NRAS Mutant Melanoma to Retinoic Acid. Med Sci Monit. 2016 Apr 22;22:1360-7. PubMed PMID: 27104669; PubMed Central PMCID: PMC4844330.
14: Carvalho-Silva R, Pereira AC, Dos Santos Alves RP, Guecheva TN, Henriques JA, Brendel M, Pungartnik C, Rios-Santos F. DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin. Evid Based Complement Alternat Med. 2016;2016:3430405. doi: 10.1155/2016/3430405. PubMed PMID: 27042187; PubMed Central PMCID: PMC4799812.
15: Qiu S, Granet R, Mbakidi JP, Brégier F, Pouget C, Micallef L, Sothea-Ouk T, Leger DY, Liagre B, Chaleix V, Sol V. Delivery of tanshinone IIA and α-mangostin from gold/PEI/cyclodextrin nanoparticle platform designed for prostate cancer chemotherapy. Bioorg Med Chem Lett. 2016 May 15;26(10):2503-6. doi: 10.1016/j.bmcl.2016.03.097. PubMed PMID: 27040657.
16: Hu Z, Wang W, Ling J, Jiang C. α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity. Cell Mol Neurobiol. 2016 Jul;36(5):811-20. doi: 10.1007/s10571-015-0264-9. PubMed PMID: 27002719; PubMed Central PMCID: PMC4894924.
17: Lee HN, Jang HY, Kim HJ, Shin SA, Choo GS, Park YS, Kim SK, Jung JY. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.)in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48. doi: 10.3892/ijmm.2016.2517. PubMed PMID: 26951885; PubMed Central PMCID: PMC4790674.
18: Franceschelli S, Pesce M, Ferrone A, Patruno A, Pasqualone L, Carlucci G, Ferrone V, Carlucci M, de Lutiis MA, Grilli A, Felaco M, Speranza L. A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway. J Cell Physiol. 2016 Nov;231(11):2439-51. doi: 10.1002/jcp.25348. PubMed PMID: 26895796.
19: Kritsanawong S, Innajak S, Imoto M, Watanapokasin R. Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells. Int J Oncol. 2016 May;48(5):2155-65. doi: 10.3892/ijo.2016.3399. PubMed PMID: 26892433.
20: Fang Y, Su T, Qiu X, Mao P, Xu Y, Hu Z, Zhang Y, Zheng X, Xie P, Liu Q. Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death. Sci Rep. 2016 Feb 18;6:21018. doi: 10.1038/srep21018. PubMed PMID: 26888416; PubMed Central PMCID: PMC4757868.
2: Lee KW, Ryu HW, Oh SS, Park S, Madhi H, Yoo J, Park KH, Kim KD. Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy. Exp Dermatol. 2016 Oct 7. doi: 10.1111/exd.13233. [Epub ahead of print] PubMed PMID: 27714857.
3: Verma RK, Yu W, Shrivastava A, Shankar S, Srivastava RK. α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice. Sci Rep. 2016 Sep 14;6:32743. doi: 10.1038/srep32743. PubMed PMID: 27624879; PubMed Central PMCID: PMC5021984.
4: Guo M, Wang X, Lu X, Wang H, Brodelius PE. α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF. PLoS One. 2016 Sep 1;11(9):e0161566. doi: 10.1371/journal.pone.0161566. PubMed PMID: 27584012; PubMed Central PMCID: PMC5008840.
5: Phitaktim S, Chomnawang M, Sirichaiwetchakoon K, Dunkhunthod B, Hobbs G, Eumkeb G. Synergism and the mechanism of action of the combination of α-mangostin isolated from Garcinia mangostana L. and oxacillin against an oxacillin-resistant Staphylococcus saprophyticus. BMC Microbiol. 2016 Aug 26;16(1):195. doi: 10.1186/s12866-016-0814-4. PubMed PMID: 27566110; PubMed Central PMCID: PMC5002192.
6: Kwak HH, Kim IR, Kim HJ, Park BS, Yu SB. α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell. Evid Based Complement Alternat Med. 2016;2016:5352412. doi: 10.1155/2016/5352412. PubMed PMID: 27478478; PubMed Central PMCID: PMC4960343.
7: Nava Catorce M, Acero G, Pedraza-Chaverri J, Fragoso G, Govezensky T, Gevorkian G. Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. J Neuroimmunol. 2016 Aug 15;297:20-7. doi: 10.1016/j.jneuroim.2016.05.008. PubMed PMID: 27397072.
8: Kaomongkolgit R, Jamdee K. Inhibitory effect of alpha-mangostin on Candida biofilms. Odontology. 2016 Jul 1. [Epub ahead of print] PubMed PMID: 27368963.
9: Lee D, Choi YO, Kim KH, Chin YW, Namgung H, Yamabe N, Jung K. Protective effect of α-mangostin against iodixanol-induced apoptotic damage in LLC-PK1 cells. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3806-9. doi: 10.1016/j.bmcl.2016.05.031. PubMed PMID: 27293071.
10: Mekseepralard C, Areebambud C, Suksamrarn S, Jariyapongskul A. Effects of Long-Term Alpha-mangostin Supplementation on Hyperglycemia and Insulin Resistance in Type 2 Diabetic Rats Induced by High Fat Diet and Low Dose Streptozotocin. J Med Assoc Thai. 2015 Nov;98 Suppl 10:S23-30. PubMed PMID: 27276829.
11: Willson CM, Grundmann O. In vitro assays in natural products research - a matter of concentration and relevance to in vivo administration using resveratrol, α-mangostin/γ-mangostin and xanthohumol as examples. Nat Prod Res. 2016 May 27:1-15. [Epub ahead of print] PubMed PMID: 27234135.
12: Xia Y, Li Y, Westover KD, Sun J, Chen H, Zhang J, Fisher DE. Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin. PLoS One. 2016 May 6;11(5):e0155217. doi: 10.1371/journal.pone.0155217. PubMed PMID: 27152946; PubMed Central PMCID: PMC4859503.
13: Xia Y, Chen J, Gong C, Chen H, Sun J. α-Mangostin, a Natural Agent, Enhances the Response of NRAS Mutant Melanoma to Retinoic Acid. Med Sci Monit. 2016 Apr 22;22:1360-7. PubMed PMID: 27104669; PubMed Central PMCID: PMC4844330.
14: Carvalho-Silva R, Pereira AC, Dos Santos Alves RP, Guecheva TN, Henriques JA, Brendel M, Pungartnik C, Rios-Santos F. DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin. Evid Based Complement Alternat Med. 2016;2016:3430405. doi: 10.1155/2016/3430405. PubMed PMID: 27042187; PubMed Central PMCID: PMC4799812.
15: Qiu S, Granet R, Mbakidi JP, Brégier F, Pouget C, Micallef L, Sothea-Ouk T, Leger DY, Liagre B, Chaleix V, Sol V. Delivery of tanshinone IIA and α-mangostin from gold/PEI/cyclodextrin nanoparticle platform designed for prostate cancer chemotherapy. Bioorg Med Chem Lett. 2016 May 15;26(10):2503-6. doi: 10.1016/j.bmcl.2016.03.097. PubMed PMID: 27040657.
16: Hu Z, Wang W, Ling J, Jiang C. α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity. Cell Mol Neurobiol. 2016 Jul;36(5):811-20. doi: 10.1007/s10571-015-0264-9. PubMed PMID: 27002719; PubMed Central PMCID: PMC4894924.
17: Lee HN, Jang HY, Kim HJ, Shin SA, Choo GS, Park YS, Kim SK, Jung JY. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.)in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48. doi: 10.3892/ijmm.2016.2517. PubMed PMID: 26951885; PubMed Central PMCID: PMC4790674.
18: Franceschelli S, Pesce M, Ferrone A, Patruno A, Pasqualone L, Carlucci G, Ferrone V, Carlucci M, de Lutiis MA, Grilli A, Felaco M, Speranza L. A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway. J Cell Physiol. 2016 Nov;231(11):2439-51. doi: 10.1002/jcp.25348. PubMed PMID: 26895796.
19: Kritsanawong S, Innajak S, Imoto M, Watanapokasin R. Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells. Int J Oncol. 2016 May;48(5):2155-65. doi: 10.3892/ijo.2016.3399. PubMed PMID: 26892433.
20: Fang Y, Su T, Qiu X, Mao P, Xu Y, Hu Z, Zhang Y, Zheng X, Xie P, Liu Q. Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death. Sci Rep. 2016 Feb 18;6:21018. doi: 10.1038/srep21018. PubMed PMID: 26888416; PubMed Central PMCID: PMC4757868.
| Chemical | |
|---|---|
| CAS Num | 6147-11-1 |
| Chemical Formula | C24H26O6 |
| Molecular Weight | 410.46 |
| IUPAC Chemical Name | 3,6,8-Trihydroxy-2-methoxy-1,7-bis(3-methylbut-2-enyl)xanthen-9-one |
| Exact Mass | 410.17294 |
| Elemental Analysis | C, 70.23; H, 6.38; O, 23.39 |
| Synonym | Alpha-Mangostin; NSC 139154; NSC 27593; NSC 30552; NSC139154; NSC27593; NSC30552. |
| Solubility | Soluble in DMSO. |
| SMILES Code | O=C1C2=C(OC3=C1C(O)=C(C/C=C(C)\C)C(O)=C3)C=C(O)C(OC)=C2C/C=C(C)\C |
| Biological | |
| Targets and Effects | xanthonoid |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Yellow solid powder |
| Purity | >95% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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