1: Malih S, Najafi R. AdipoRon: a possible drug for colorectal cancer prevention? Tumour Biol. 2015 Aug 18. [Epub ahead of print] PubMed PMID: 26282004.   2: Zhang Y, Zhao J, Li R, Lau WB, Yuan YX, Liang B, Li R, Gao EH, Koch WJ, Ma XL, Wang YJ. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82. doi: 10.1152/ajpendo.00577.2014. Epub 2015 Jun 2. PubMed PMID:  26037251; PubMed Central PMCID: PMC4525114.   3: Dib J, Schlörer N, Schänzer W, Thevis M. Studies on the collision-induced dissociation of adipoR agonists after electrospray ionization and their implementation in sports drug testing. J Mass Spectrom. 2015 Feb;50(2):407-17. doi: 10.1002/jms.3545. PubMed PMID: 25800023.   4: Lee S, Kwak HB. Role of adiponectin in metabolic and cardiovascular disease. J Exerc Rehabil. 2014 Apr 30;10(2):54-9. doi: 10.12965/jer.140100. eCollection 2014 Apr. Review. PubMed PMID: 24877038; PubMed Central PMCID: PMC4025550.   5: Holland WL, Scherer PE. Cell Biology. Ronning after the adiponectin receptors. Science. 2013 Dec 20;342(6165):1460-1. doi: 10.1126/science.1249077. PubMed PMID: 24357309; PubMed Central PMCID: PMC4084614.   6: Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi  M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T,  Tanaka A, Yokoyama S, Kadowaki T. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. doi: 10.1038/nature12656. Epub 2013 Oct 30. PubMed PMID: 24172895.

Chemical
CAS Num	924416-43-3
Chemical Formula	C27H28N2O3
Molecular Weight	428.52
IUPAC Chemical Name	2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
Exact Mass	428.20999
Elemental Analysis	C, 75.68; H, 6.59; N, 6.54; O, 11.20
Synonym	AdipoRon;
Solubility	Soluble in DMSO, not in water
SMILES Code	O=C(C1=CC=C(OCC(NC2CCN(CC3=CC=CC=C3)CC2)=O)C=C1)C4=CC=CC=C4
Biological
Targets and Effects	AMPK Agonist
Pathways	Apoptosis
Physical
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life	>2 years if stored properly