3-Bromopyruvic acid
Bromopyruvic acid is a hexokinase II inhibitor and an effective antitumor agent. The characteristics of 3-bromopyruvate in vitro and in vivo have been reported in the scientific literature since the 1940s. Because it is a highly reactive alkylating agent and it is inherently unstable, it had been described as a metabolic poison. Research at Johns Hopkins has suggested that 3-bromopyruvate could be used to selectively kill cancer cells, while leaving normal cells intact. Recently, the FDA accepted an IND application for the use of 3-bromopyruvate for a Phase I clinical trial in liver cancer.
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| Chemical | |
|---|---|
| CAS Num | 113-59-3 |
| Chemical Formula | C3H3BrO3 |
| Molecular Weight | 166.96 |
| IUPAC Chemical Name | 3-bromo-2-oxopropanoic acid |
| Exact Mass | 165.92656 |
| Elemental Analysis | C, 21.58; H, 1.81; Br, 47.86; O, 28.75 |
| Synonym | 3-BrPA; 3-BP; BPV; NSC 11731; NSC-11731; NSC11731; NSC 62343; NSC62343; NSC-62343; SBB053571; BRN 1746786; Bromopyruvic acid; 3-Bromopyruvic acid, bromopyruvic acid; 3-bromo-2-oxopropanoic acid; brom |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | O=C(CBr)C(O)=O |
| Biological | |
| Targets and Effects | hexokinase II inhibitor |
| Pathways | alkylating agent |
| Physical | |
| Appearance | Solid powder |
| Purity | >97% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >10 years if stored properly |
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