ABT-767
ABT-767 is an orally available inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, ABT-767 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. ABT-767 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.
| Chemical | |
|---|---|
| CAS Num | NONE |
| IUPAC Chemical Name | NONE |
| Synonym | ABT767; ABT 767; ABT-767 |
| Solubility | Soluble in DMSO, not in water |
| Biological | |
| Targets and Effects | PARP inhibitor |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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Anba Pharma Company
3-H Gill Street, Suite 300
Woburn, MA 01801
United State
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Tel: 1+610-883-0668
Email: sales@AnbaPharma.com