AG-1024
AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Tyrphostin AG 1024 could be used as a potential therapeutic agent in combination with irradiation.
1: Wen B, Deutsch E, Marangoni E, Frascona V, Maggiorella L, Abdulkarim B, Chavaudra N, Bourhis J. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. Br J Cancer. 2001 Dec 14;85(12):2017-21. PubMed PMID: 11747348; PubMed Central PMCID: PMC2364012.
| Chemical | |
|---|---|
| CAS Num | 65678-07-1 |
| Chemical Formula | C14H13BrN2O |
| Molecular Weight | 305.16982 |
| IUPAC Chemical Name | 2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile |
| Exact Mass | 304.02113 |
| Elemental Analysis | C, 55.10; H, 4.29; Br, 26.18; N, 9.18; O, 5.24 |
| Synonym | AG1024; AG-1024; AG 1024. Tyrphostin. |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | N#C/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(Br)=C1 |
| Biological | |
| Targets and Effects | IGF-1R |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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