APG-1387
APG-1387, also known as SM-1387, is a IAP inhibitor. APG-1387 promotes the rapid degradation of cIAP1/2 and XIAP, and it exerts an antitumor effect on nasopharyngeal carcinoma cancer stem cells. Further studies show that APG-1387 enhances the chemosensitivity and promotes apoptosis in combination with CDDP and 5-FU of NPC in vitro and vivo.
| Chemical | |
|---|---|
| CAS Num | Unknown |
| IUPAC Chemical Name | Unknown |
| Synonym | APG-1387, APG 1387l; APG1387; SM-1387; SM 1387; SM1387. |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | Unknown |
| Biological | |
| Targets and Effects | IAP inhibitor |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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