Bioymifi
Bioymifi is an DR5 activator (Kd = 1.2 µM; IC50 = 2 µM). Bioymifi induces apoptosis via the Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) death receptor DR5 independent of TRAIL. Bioymifi can act as a single agent to induce DR5 clustering and aggregation, leading to apoptosis. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) activates apoptosis through the death receptors DR4 and DR5.
1: Wang G, Wang X, Yu H, Wei S, Williams N, Holmes DL, Halfmann R, Naidoo J, Wang L, Li L, Chen S, Harran P, Lei X, Wang X. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol. 2013 Feb;9(2):84-9. doi: 10.1038/nchembio.1153. PubMed PMID: 23292651.
| Chemical | |
|---|---|
| CAS Num | 1420071-30-2 |
| Chemical Formula | C22H12BrN3O4S |
| Molecular Weight | 494.319 |
| IUPAC Chemical Name | (Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione |
| Exact Mass | 492.9732 |
| Elemental Analysis | C, 53.46; H, 2.45; Br, 16.16; N, 8.50; O, 12.95; S, 6.49 |
| Synonym | Bioymifi |
| Solubility | Soluble in DMSO |
| SMILES Code | O=C1NC(C2=C1C=CC(C3=CC=C(/C=C(SC(N4C5=CC=C(Br)C=C5)=N)/C4=O)O3)=C2)=O |
| Biological | |
| Targets and Effects | N/A |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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