Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily.
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Chemical |
CAS Num |
154-93-8 |
Chemical Formula |
C5H9Cl2N3O2 |
Molecular Weight |
214.05 |
IUPAC Chemical Name |
1,3-bis(2-chloroethyl)-1-nitrosourea |
Exact Mass |
213.00718 |
Elemental Analysis |
C, 28.06; H, 4.24; Cl, 33.13; N, 19.63; O, 14.95 |
Synonym |
Synonyms |
Solubility |
Soluble in DMSO, not in water |
SMILES Code |
O=C(NCCCl)N(CCCl)N=O |
Biological |
Targets and Effects |
N/A |
Pathways |
alkylating agent |
Physical |
Appearance |
Solid powder |
Purity |
>98% (or refer to the Certificate of Analysis) |
Shipping Condition |
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition |
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Shelf Life |
>2 years if stored properly |