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Anba Pharma Chlorambucil CAS No.: 305-03-3 .. Product #: Anba-004452 Regular price: $140.00 $140.00

Chlorambucil

Catalog No.: Anba-004452
Weight: 100mg

Price: $140.00

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Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.

1: Rehman SU, Sarwar T, Ishqi HM, Husain MA, Hasan Z, Tabish M. Deciphering the interactions between chlorambucil and calf thymus DNA: A multi-spectroscopic and molecular docking study. Arch Biochem Biophys. 2015 Jan 15;566:7-14. doi: 10.1016/j.abb.2014.12.013. Epub 2014 Dec 17. PubMed PMID: 25528167.
2: Soler M, González-Bártulos M, Figueras E, Ribas X, Costas M, Massaguer A, Planas M, Feliu L. Enzyme-triggered delivery of chlorambucil from conjugates based on the cell-penetrating peptide BP16. Org Biomol Chem. 2015 Jan 21;13(5):1470-80. doi: 10.1039/c4ob01875c. PubMed PMID: 25474438.
3: Nazarov AA, Meier SM, Zava O, Nosova YN, Milaeva ER, Hartinger CG, Dyson PJ. Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity. Dalton Trans. 2014 Nov 13. [Epub ahead of print] PubMed PMID: 25407500.
4: Wang X, Li J, Xu C, Li Y, Gong T, Sun X, Fu Y, He Q, Zhang Z. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjug Chem. 2014 Nov 19;25(11):2046-54. doi: 10.1021/bc5004108. Epub 2014 Nov 6. PubMed PMID: 25350514.
5: Olayinka ET, Ore A. Kolaviron and L-ascorbic Acid attenuate chlorambucil-induced testicular oxidative stress in rats. J Toxicol. 2014;2014:587015. doi: 10.1155/2014/587015. Epub 2014 Sep 17. PubMed PMID: 25309592; PubMed Central PMCID: PMC4182070.
6: Goede V, Eichhorst B, Fischer K, Wendtner CM, Hallek M. Past, present and future role of chlorambucil in the treatment of chronic lymphocytic leukemia. Leuk Lymphoma. 2014 Nov 20:1-8. [Epub ahead of print] PubMed PMID: 25219593.
7: López-Lluva MT, de la Nieta-García MD, Piqueras-Flores J, Arambarri-Segura M, Martínez-Calero A, Rivera-Hernández F. Chlorambucil-induced cytomegalovirus infection: a case report. J Med Case Rep. 2014 Aug 20;8:280. doi: 10.1186/1752-1947-8-280. PubMed PMID: 25142684; PubMed Central PMCID: PMC4164317.
8: Asamitsu S, Kawamoto Y, Hashiya F, Hashiya K, Yamamoto M, Kizaki S, Bando T, Sugiyama H. Sequence-specific DNA alkylation and transcriptional inhibition by long-chain hairpin pyrrole-imidazole polyamide-chlorambucil conjugates targeting CAG/CTG trinucleotide repeats. Bioorg Med Chem. 2014 Sep 1;22(17):4646-57. doi: 10.1016/j.bmc.2014.07.019. Epub 2014 Jul 22. PubMed PMID: 25127467.
9: Wang X, Zhang Q, Lin Q, Zhang Y, Zhang ZR. Validated LC-MS/MS method for the simultaneous determination of chlorambucil and its prodrug in mouse plasma and brain, and application to pharmacokinetics. J Pharm Biomed Anal. 2014 Oct;99:74-8. doi: 10.1016/j.jpba.2014.07.010. Epub 2014 Jul 17. PubMed PMID: 25090578.
10: Martinelli G, Montoro J, Vanazzi A, Andreola G, Liptrott S, Radice D, Negri M, Preda L, Pruneri G, Laszlo D. Chlorambucil-rituximab as first-line therapy in patients affected by follicular non-Hodgkin's lymphoma: a retrospective single-centre study. Hematol Oncol. 2014 Jul 22. doi: 10.1002/hon.2154. [Epub ahead of print] PubMed PMID: 25047267.
Chemical
CAS Num 305-03-3
Chemical Formula C14H19Cl2NO2
Molecular Weight 304.21
IUPAC Chemical Name 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoic acid
Exact Mass 303.07928
Elemental Analysis C, 55.27; H, 6.30; Cl, 23.31; N, 4.60; O, 10.52
Synonym chlorambucilum; chloraminophen; Chlorbutin; chlorbutine; chlorbutinum; chloroambucil; chlorobutin; chlorobutine; Leukersan; Leukoran; Lympholysin; phenylbutyric acid nitrogen mustard; US brand names
Solubility Soluble in DMSO, not in water
SMILES Code O=C(O)CCCC1=CC=C(N(CCCl)CCCl)C=C1
Biological
Targets and Effects N/A
Pathways alkylating agent
Physical
Appearance Solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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