Chlorambucil is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
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Chemical |
CAS Num |
305-03-3 |
Chemical Formula |
C14H19Cl2NO2 |
Molecular Weight |
304.21 |
IUPAC Chemical Name |
4-(4-(bis(2-chloroethyl)amino)phenyl)butanoic acid |
Exact Mass |
303.07928 |
Elemental Analysis |
C, 55.27; H, 6.30; Cl, 23.31; N, 4.60; O, 10.52 |
Synonym |
chlorambucilum; chloraminophen; Chlorbutin; chlorbutine; chlorbutinum; chloroambucil; chlorobutin; chlorobutine; Leukersan; Leukoran; Lympholysin; phenylbutyric acid nitrogen mustard; US brand names |
Solubility |
Soluble in DMSO, not in water |
SMILES Code |
O=C(O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 |
Biological |
Targets and Effects |
N/A |
Pathways |
alkylating agent |
Physical |
Appearance |
Solid powder |
Purity |
>98% (or refer to the Certificate of Analysis) |
Shipping Condition |
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition |
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Shelf Life |
>2 years if stored properly |