Citarinostat
Citarinostat, also known as ACY-241, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activity of HDACs; this results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibit tumor cell division and induce tumor cell apoptosis.
| Chemical | |
|---|---|
| CAS Num | 1316215-12-9 |
| Chemical Formula | C24H26ClN5O3 |
| Molecular Weight | 467.954 |
| IUPAC Chemical Name | 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide |
| Exact Mass | 467.1724 |
| Elemental Analysis | C, 61.60; H, 5.60; Cl, 7.58; N, 14.97; O, 10.26 |
| Synonym | ACY-241; ACY 241; ACY241; HDAC-IN-2; Citarinostat. |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | ClC1=CC=CC=C1N(C2=CC=CC=C2)C3=NC=C(C=N3)C(NCCCCCCC(NO)=O)=O |
| Biological | |
| Targets and Effects | HDAC Inhibitor |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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