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Anba Pharma CUR-61414 CAS No.: 334998-36-6 .. Product #: Anba-004812

CUR-61414

Catalog No.: Anba-004812
Weight: 0
Call for Price: 610-883-0668

CUR-61414, also known as G-024856 and G-856, is a smoothened receptor antagonist potentially for the treatment of basal cell carcinoma. CUR61414 significantly inhibited skin Hedgehog signaling, blocked the induction of hair follicle anagen, and shrank existing basal cell carcinomas. CUR61414 can suppress proliferation and induce apoptosis of basaloid nests in the basal cell carcinoma model systems, whereas having no effect on normal skin cells.

1: Shin YG, Murakami SC, Buonarati MH, Dean B, Hop CE. Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of G-856 (Cur-61414) in human plasma using semi-automated solid phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 1;887-888:85-92. doi: 10.1016/j.jchromb.2012.01.016. PubMed PMID: 22317788.
2: Williams JA. Hedgehog signaling pathway as a target for therapeutic intervention in basal cell carcinoma. Drug News Perspect. 2003 Dec;16(10):657-62. Review. PubMed PMID: 14747845.
3: Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst. 2010 Jan;6(1):44-54. doi: 10.1039/b910196a. Review. PubMed PMID: 20024066.
4: Lauressergues E, Heusler P, Lestienne F, Troulier D, Rauly-Lestienne I, Tourette A, Ailhaud MC, Cathala C, Tardif S, Denais-Laliève D, Calmettes MT, Degryse AD, Dumoulin A, De Vries L, Cussac D. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214. doi: 10.1002/prp2.214. PubMed PMID: 27069629; PubMed Central PMCID: PMC4804317.
5: Tang T, Tang JY, Li D, Reich M, Callahan CA, Fu L, Yauch RL, Wang F, Kotkow K, Chang KS, Shpall E, Wu A, Rubin LL, Marsters JC Jr, Epstein EH Jr, Caro I, de Sauvage FJ. Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. Clin Cancer Res. 2011 May 15;17(10):3378-87. doi: 10.1158/1078-0432.CCR-10-3370. PubMed PMID: 21558397; PubMed Central PMCID: PMC3113453.
6: Mechlin CW, Tanner MJ, Chen M, Buttyan R, Levin RM, Mian BM. Gli2 expression and human bladder transitional carcinoma cell invasiveness. J Urol. 2010 Jul;184(1):344-51. doi: 10.1016/j.juro.2010.03.007. PubMed PMID: 20488474.
7: Angot E, Loulier K, Nguyen-Ba-Charvet KT, Gadeau AP, Ruat M, Traiffort E. Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb. Stem Cells. 2008 Sep;26(9):2311-20. doi: 10.1634/stemcells.2008-0297. PubMed PMID: 18617686.
8: Masdeu C, Faure H, Coulombe J, Schoenfelder A, Mann A, Brabet I, Pin JP, Traiffort E, Ruat M. Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15. Biochem Biophys Res Commun. 2006 Oct 20;349(2):471-9. PubMed PMID: 16945339.
9: Kiselyov AS. Targeting the hedgehog signaling pathway with small molecules. Anticancer Agents Med Chem. 2006 Sep;6(5):445-9. Review. PubMed PMID: 17017853.
10: Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Wichterle H, Kon C, Gatchalian C, Porter JA, Rubin LL, Wang FY. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8607. PubMed PMID: 12679522; PubMed Central PMCID: PMC153604.
Chemical
CAS Num 334998-36-6
Chemical Formula C31H42N4O5
Molecular Weight 550.7
IUPAC Chemical Name N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl)-N-(3-methoxybenzyl)-3,3-dimethylbutanamide
Exact Mass 550.3155
Elemental Analysis C, 67.61; H, 7.69; N, 10.17; O, 14.53
Synonym CUR-61414; CUR 61414; CUR61414; G-024856; G024856; G 024856; G-856; G 856; G856
Solubility Soluble in DMSO
SMILES Code CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O
Biological
Targets and Effects N/A
Pathways Apoptosis
Physical
Appearance Solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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Woburn, MA 01801
United State

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