CUR-61414, also known as G-024856 and G-856, is a smoothened receptor antagonist potentially for the treatment of basal cell carcinoma. CUR61414 significantly inhibited skin Hedgehog signaling, blocked the induction of hair follicle anagen, and shrank existing basal cell carcinomas. CUR61414 can suppress proliferation and induce apoptosis of basaloid nests in the basal cell carcinoma model systems, whereas having no effect on normal skin cells.
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Chemical |
CAS Num |
334998-36-6 |
Chemical Formula |
C31H42N4O5 |
Molecular Weight |
550.7 |
IUPAC Chemical Name |
N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazine-1-carbonyl)pyrrolidin-3-yl)-N-(3-methoxybenzyl)-3,3-dimethylbutanamide |
Exact Mass |
550.3155 |
Elemental Analysis |
C, 67.61; H, 7.69; N, 10.17; O, 14.53 |
Synonym |
CUR-61414; CUR 61414; CUR61414; G-024856; G024856; G 024856; G-856; G 856; G856 |
Solubility |
Soluble in DMSO |
SMILES Code |
CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O |
Biological |
Targets and Effects |
N/A |
Pathways |
Apoptosis |
Physical |
Appearance |
Solid powder |
Purity |
>98% (or refer to the Certificate of Analysis) |
Shipping Condition |
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition |
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Shelf Life |
>2 years if stored properly |