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2: Ravi D, Bhalla S, Gartenhaus RB, Crombie J, Kandela I, Sharma J, Mazar A, Evens AM. The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. Clin Cancer Res. 2014 Dec 1;20(23):6023-33. doi: 10.1158/1078-0432.CCR-14-1532. Epub 2014 Oct 14. PubMed PMID: 25316819; PubMed Central PMCID: PMC4281835.
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4: Garnier N, Redstone GG, Dahabieh MS, Nichol JN, del Rincon SV, Gu Y, Bohle DS, Sun Y, Conklin DS, Mann KK, Miller WH Jr. The novel arsenical darinaparsin is transported by cystine importing systems. Mol Pharmacol. 2014 Apr;85(4):576-85. doi: 10.1124/mol.113.089433. Epub 2014 Jan 15. PubMed PMID: 24431147.
5: Tian J, Doi H, Saar M, Santos J, Li X, Peehl DM, Knox SJ. Radioprotection and cell cycle arrest of intestinal epithelial cells by darinaparsin, a tumor radiosensitizer. Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):1179-85. doi: 10.1016/j.ijrobp.2013.08.051. Epub 2013 Oct 24. PubMed PMID: 24210080.
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Chemical
CAS Num	69819-86-9
Chemical Formula	C12H22AsN3O6S
Molecular Weight	411.31
IUPAC Chemical Name	(S)-2-amino-5-(((R)-1-((carboxymethyl)amino)-3-((dimethylarsino)thio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid
Exact Mass	411.04453
Elemental Analysis	C, 35.04; H, 5.39; As, 18.22; N, 10.22; O, 23.34; S, 7.80
Synonym	ZIO 101; ZIO101; ZIO-101. Darinaparsin; Zinapar.
Solubility	Soluble in water
SMILES Code	O=C(O)[C@@H](N)CCC(N[C@@H](CS[As](C)C)C(NCC(O)=O)=O)=O
Biological
Targets and Effects	N/A
Pathways	Apoptosis
Physical
Appearance	White to off-white solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life	>2 years if stored properly