1: Zhou XL, Huang L, Cao J. Embelin Reduces Systemic Inflammation and Ameliorates Organ Injuries in Septic Rats Through Downregulating STAT3 and NF-κB Pathways. Inflammation. 2015 Feb 15. [Epub ahead of print] PubMed PMID: 25682469.
2: Narayanaswamy R, Shymatak M, Chatterjee S, Wai LK, Arumugam G. Inhibition of Angiogenesis and Nitric Oxide Synthase (NOS), by Embelin & Vilangin Using in vitro, in vivo & in Silico Studies. Adv Pharm Bull. 2014 Dec;4(Suppl 2):543-8. doi: 10.5681/apb.2014.080. Epub 2014 Dec 31. PubMed PMID: 25671187; PubMed Central PMCID: PMC4312403.
3: Joy B, Kumar SN, Radhika AR, Abraham A. Embelin (2,5-Dihydroxy-3-undecyl-p-benzoquinone) for photodynamic therapy: study of their cytotoxicity in cancer cells. Appl Biochem Biotechnol. 2015 Jan;175(2):1069-79. doi: 10.1007/s12010-014-1266-7. Epub 2014 Oct 31. PubMed PMID: 25359675.
4: Yang T, Lan J, Huang Q, Chen X, Sun X, Liu X, Yang P, Jin T, Wang S, Mou X. Embelin sensitizes acute myeloid leukemia cells to TRAIL through XIAP inhibition and NF-κB inactivation. Cell Biochem Biophys. 2015 Jan;71(1):291-7. doi: 10.1007/s12013-014-0197-9. PubMed PMID: 25358405.
5: Dhanjal JK, Nigam N, Sharma S, Chaudhary A, Kaul SC, Grover A, Wadhwa R. Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence. BMC Cancer. 2014 Oct 22;14:775. doi: 10.1186/1471-2407-14-775. PubMed PMID: 25336399; PubMed Central PMCID: PMC4210574.
6: Hu R, Yang Y, Liu Z, Jiang H, Zhu K, Li J, Xu W. The XIAP inhibitor Embelin enhances TRAIL-induced apoptosis in human leukemia cells by DR4 and DR5 upregulation. Tumour Biol. 2015 Feb;36(2):769-77. doi: 10.1007/s13277-014-2702-6. Epub 2014 Oct 8. PubMed PMID: 25293521.
7: Singh B, Guru SK, Sharma R, Bharate SS, Khan IA, Bhushan S, Bharate SB, Vishwakarma RA. Synthesis and anti-proliferative activities of new derivatives of embelin. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4865-70. doi: 10.1016/j.bmcl.2014.08.052. Epub 2014 Sep 1. PubMed PMID: 25240254.
8: Joy B, Nishanth Kumar S, Soumya MS, Radhika AR, Vibin M, Abraham A. Embelin (2,5-dihydroxy-3-undecyl-p-benzoquinone): a bioactive molecule isolated from Embelia ribes as an effective photodynamic therapeutic candidate against tumor in vivo. Phytomedicine. 2014 Sep 25;21(11):1292-7. doi: 10.1016/j.phymed.2014.07.001. Epub 2014 Jul 30. PubMed PMID: 25172792.
9: Poojari RJ. Embelin, a small molecule quinone with a co-clinical power for castrate-resistant prostate cancer. Front Pharmacol. 2014 Aug 8;5:184. doi: 10.3389/fphar.2014.00184. eCollection 2014. PubMed PMID: 25152733; PubMed Central PMCID: PMC4126039.
10: Peng M, Huang B, Zhang Q, Fu S, Wang D, Cheng X, Wu X, Xue Z, Zhang L, Zhang D, Da Y, Dai Y, Yang Q, Yao Z, Qiao L, Zhang R. Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. Cancer Lett. 2014 Nov 28;354(2):407-16. doi: 10.1016/j.canlet.2014.08.011. Epub 2014 Aug 13. PubMed PMID: 25128650.

Chemical
CAS Num	550-24-3
Chemical Formula	C17H26O4
Molecular Weight	294.39
IUPAC Chemical Name	2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione
Exact Mass	294.18311
Elemental Analysis	C, 69.36; H, 8.90; O, 21.74
Synonym	NSC91874; NSC91874; NSC 91874; Embelin; Emberine; Embelic acid.
Solubility	Soluble to 10 mM in ethanol with gentle warming and to 100 mM in DMSO, not soluble in water
SMILES Code	O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O
Biological
Targets and Effects	Apoptosis Protein inhibitor
Pathways	Apoptosis
Physical
Appearance	Solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life	>2 years if stored properly