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Anba Pharma Gemcitabine Hydrochloride CAS No.: 122111-03-9 (HCl) .. Product #: Anba-000967 Regular price: $140.00 $140.00

Gemcitabine Hydrochloride

Catalog No.: Anba-000967
Weight: 1g

Price: $140.00

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Gemcitabine hydrochloride is the hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis.

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Chemical
CAS Num 122111-03-9 (HCl)
Chemical Formula C9H12ClF2N3O4
Molecular Weight 299.66
IUPAC Chemical Name 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride
Elemental Analysis C, 36.07; H, 4.04; Cl, 11.83; F, 12.68; N, 14.02; O, 21.36
Synonym LY188011; LY-188011; LY 188011; Abbreviations
Solubility Soluble in DMSO at 12.5 mg/mL with slight warming; very poorly soluble in ethanol; soluble in water at 25 mg/mL with slight warming.
SMILES Code O=C1N=C(N)C=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F.[H]Cl
Biological
Targets and Effects ribonucleotide reductase inhibitor
Pathways Apoptosis
Physical
Appearance white solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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Woburn, MA 01801
United State

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