GPX150 (CNDO1011) HCl salt
GPX-150, also known as CNDO1011, is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
1. Zhang; Xini (Hoover, AL), Olson; Richard D. (Nampa, ID) 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them, United States Patent 5942605.
| Chemical | |
|---|---|
| CAS Num | 236095-29-7 |
| Chemical Formula | C27H33ClN2O9 |
| Molecular Weight | 565.02 |
| IUPAC Chemical Name | (8R,10S)-10-(((2S,4S,5R,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyethyl)-12-imino-1-methoxy-7,8,9,10-tetrahydrotetracen-5(12H)-one hydrchloride |
| Elemental Analysis | C, 57.40; H, 5.89; Cl, 6.27; N, 4.96; O, 25.48 |
| Synonym | CNDO1011; CNDO-1011; CNDO 1011; GPX150; GPX 150; GPX-150. |
| Solubility | Soluble in DMSO, not soluble in water. |
| SMILES Code | O=C1C2=C(O)C(C[C@](CCO)(O)C[C@@H]3O[C@@H]4C[C@H](N)[C@@H](O)[C@H](C)O4)=C3C(O)=C2C(C5=C1C=CC=C5OC)=N.[H]Cl |
| Biological | |
| Targets and Effects | topoisomerase II |
| Pathways | Apoptosis |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >5 years if stored properly |
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