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Anba Pharma GYKI-13324 CAS No.: 76123-41-6 .. Product #: Anba-001307

GYKI-13324

Catalog No.: Anba-001307
Weight: 0
Call for Price: 610-883-0668

GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. GYKI-13324 was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors.

1: Pál K, Kopper L, Lapis K. Chemotherapeutic sensitivity of liver metastases from intrasplenically-growing Lewis lung tumor. Clin Exp Metastasis. 1983 Oct-Dec;1(4):341-7. PubMed PMID: 6443744.
2: Kopper L, Lapis K, Csányi E, Horváth T. Effect of a new bifunctional nitrosoureido derivative on human colorectal tumor xenografts. Anticancer Res. 1981;1(4):229-33. PubMed PMID: 7345967.
3: Csányi E, Horváth T, Király E, Lapis K, Kopper L. New type bifunctional nitrosoureido derivatives with cytostatic activity. Oncology. 1980;37 Suppl 1:59-66. PubMed PMID: 7454201.
Chemical
CAS Num 76123-41-6
Chemical Formula C10H18Cl2N6O6
Molecular Weight 389.19
IUPAC Chemical Name N-(2-Chloroethyl)-N'-(4-((((2-chloroethyl)amino)carbonyl)nitrosamino)-2,3-dihydroxybutyl)-N-nitrosourea
Exact Mass 388.0665
Elemental Analysis C, 30.86; H, 4.66; Cl, 18.22; N, 21.59; O, 24.67
Synonym GYKI-13324; GYKI 13324; GYKI13324.
Solubility Soluble in DMSO, not in water
SMILES Code O=C(NCC(O)C(O)CN(C(NCCCl)=O)N=O)N(CCCl)N=O
Biological
Targets and Effects N/A
Pathways alkylating agent
Physical
Appearance Solid powder
Purity >98% (or refer to the Certificate of Analysis)
Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life >2 years if stored properly

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