GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. GYKI-13324 was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors.
| Chemical | |
|---|---|
| CAS Num | 76123-41-6 | 
| Chemical Formula | C10H18Cl2N6O6 | 
| Molecular Weight | 389.19 | 
| IUPAC Chemical Name | N-(2-Chloroethyl)-N'-(4-((((2-chloroethyl)amino)carbonyl)nitrosamino)-2,3-dihydroxybutyl)-N-nitrosourea | 
| Exact Mass | 388.0665 | 
| Elemental Analysis | C, 30.86; H, 4.66; Cl, 18.22; N, 21.59; O, 24.67 | 
| Synonym | GYKI-13324; GYKI 13324; GYKI13324. | 
| Solubility | Soluble in DMSO, not in water | 
| SMILES Code | O=C(NCC(O)C(O)CN(C(NCCCl)=O)N=O)N(CCCl)N=O | 
| Biological | |
| Targets and Effects | N/A | 
| Pathways | alkylating agent | 
| Physical | |
| Appearance | Solid powder | 
| Purity | >98% (or refer to the Certificate of Analysis) | 
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. | 
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). | 
| Shelf Life | >2 years if stored properly | 
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