GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. GYKI-13324 was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors.
Chemical | |
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CAS Num | 76123-41-6 |
Chemical Formula | C10H18Cl2N6O6 |
Molecular Weight | 389.19 |
IUPAC Chemical Name | N-(2-Chloroethyl)-N'-(4-((((2-chloroethyl)amino)carbonyl)nitrosamino)-2,3-dihydroxybutyl)-N-nitrosourea |
Exact Mass | 388.0665 |
Elemental Analysis | C, 30.86; H, 4.66; Cl, 18.22; N, 21.59; O, 24.67 |
Synonym | GYKI-13324; GYKI 13324; GYKI13324. |
Solubility | Soluble in DMSO, not in water |
SMILES Code | O=C(NCC(O)C(O)CN(C(NCCCl)=O)N=O)N(CCCl)N=O |
Biological | |
Targets and Effects | N/A |
Pathways | alkylating agent |
Physical | |
Appearance | Solid powder |
Purity | >98% (or refer to the Certificate of Analysis) |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Shelf Life | >2 years if stored properly |
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