Ifosfamide
Ifosfamide is a synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
| Chemical | |
|---|---|
| CAS Num | 3778-73-2 |
| Chemical Formula | C7H15Cl2N2O2P |
| Molecular Weight | 261.09 |
| IUPAC Chemical Name | 3-(2-chloroethyl)-2-((2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide |
| Exact Mass | 260.02482 |
| Elemental Analysis | C, 32.20; H, 5.79; Cl, 27.16; N, 10.73; O, 12.26; P, 11.86 |
| Synonym | Ifomide; Iphosphamid; iphosphamide; Isoendoxan; IsoEndoxan; isophosphamide; Naxamide; US brand names |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | ClCCNP1(OCCCN1CCCl)=O |
| Biological | |
| Targets and Effects | N/A |
| Pathways | alkylating agent |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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