1: Cheng X, Gu J, Zhang M, Yuan J, Zhao B, Jiang J, Jia X. Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-α-ERK1/2-NF-κB pathway. Int Immunopharmacol. 2014 Sep 10. pii: S1567-5769(14)00341-5. doi: 10.1016/j.intimp.2014.08.027. [Epub ahead of print] PubMed PMID: 25218161.
2: Zhang X, Chen J. The mechanism of astragaloside IV promoting sciatic nerve regeneration. Neural Regen Res. 2013 Aug 25;8(24):2256-65. doi: 10.3969/j.issn.1673-5374.2013.24.005. PubMed PMID: 25206535; PubMed Central PMCID: PMC4146037.
3: Chen Z, Cai Y, Zhang W, Liu X, Liu S. Astragaloside IV inhibits platelet-derived growth factor-BB-stimulated proliferation and migration of vascular smooth muscle cells via the inhibition of p38 MAPK signaling. Exp Ther Med. 2014 Oct;8(4):1253-1258. Epub 2014 Aug 14. PubMed PMID: 25187834; PubMed Central PMCID: PMC4151649.
4: Qiu YY, Zhu JX, Bian T, Gao F, Qian XF, Du Q, Yuan MY, Sun H, Shi LZ, Yu MH. Protective Effects of Astragaloside IV against Ovalbumin-Induced Lung Inflammation Are Regulated/Mediated by T-bet/GATA-3. Pharmacology. 2014 Aug 28;94(1-2):51-59. [Epub ahead of print] PubMed PMID: 25171656.
5: Shao A, Guo S, Tu S, Ammar AB, Tang J, Hong Y, Wu H, Zhang J. Astragaloside IV alleviates early brain injury following experimental subarachnoid hemorrhage in rats. Int J Med Sci. 2014 Aug 8;11(10):1073-81. doi: 10.7150/ijms.9282. eCollection 2014. PubMed PMID: 25136262; PubMed Central PMCID: PMC4135229.
6: Chen Y, Gui D, Chen J, He D, Luo Y, Wang N. Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats. Cell Physiol Biochem. 2014;33(6):1975-87. PubMed PMID: 25012492.
7: Liu QS, Wang HF, Sun AK, Huo XP, Liu JL, Ma SH, Peng N, Hu J. A comparative study on inhibition of total astragalus saponins and astragaloside IV on TNFR1-mediated signaling pathways in arterial endothelial cells. PLoS One. 2014 Jul 3;9(7):e101504. doi: 10.1371/journal.pone.0101504. eCollection 2014. PubMed PMID: 24991819; PubMed Central PMCID: PMC4081628.
8: Zhang A, Zheng Y, Que Z, Zhang L, Lin S, Le V, Liu J, Tian J. Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO. J Cancer Res Clin Oncol. 2014 Jul 1. [Epub ahead of print] PubMed PMID: 24980548.
9: Xu W, Shao X, Tian L, Gu L, Zhang M, Wang Q, Wu B, Wang L, Yao J, Xu X, Mou S, Ni Z. Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro. J Pharmacol Exp Ther. 2014 Sep;350(3):552-62. doi: 10.1124/jpet.114.214205. Epub 2014 Jun 20. PubMed PMID: 24951279.
10: Sun Q, Jia N, Wang W, Jin H, Xu J, Hu H. Protective effects of astragaloside IV against amyloid beta1-42 neurotoxicity by inhibiting the mitochondrial permeability transition pore opening. PLoS One. 2014 Jun 6;9(6):e98866. doi: 10.1371/journal.pone.0098866. eCollection 2014. PubMed PMID: 24905226; PubMed Central PMCID: PMC4048237.

Chemical
CAS Num	84687-43-4
Chemical Formula	C41H68O14
Molecular Weight	784.97
IUPAC Chemical Name	(2R,3R,4S,5S,6R)-2-(((2aR,3R,4R,5aS,7R,11aR)-4-hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)hexadecahydrocyclopenta[a]cyclopropa[e]phenanthre
Exact Mass	784.46091
Elemental Analysis	C, 62.73; H, 8.73; O, 28.54
Synonym	Astragaloside IV
Solubility	Soluble in DMSO.
SMILES Code	C[C@]12CCC34C[C@@]35CCC(O[C@H]6[C@H](O)[C@@H](O)[C@H](O)CO6)C(C)(C)C5[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)CC4[C@]1(C)C[C@@H](O)[C@@H]2[C@@]8(C)CC[C@@H](C(C)(O)C)O8
Biological
Targets and Effects	NA
Pathways	Apoptosis
Physical
Appearance	solid powder
Purity	>98% (or refer to the Certificate of Analysis)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shelf Life	>2 years if stored properly