Etoricoxib is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.
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Chemical |
CAS Num |
202409-33-4 |
Chemical Formula |
C18H15ClN2O2S |
Molecular Weight |
358.8419 |
IUPAC Chemical Name |
5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine |
Exact Mass |
358.0543 |
Elemental Analysis |
C, 60.25; H, 4.21; Cl, 9.88; N, 7.81; O, 8.92; S, 8.94 |
Synonym |
Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663 |
Solubility |
Soluble in DMSO, not in water |
SMILES Code |
O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O |
Biological |
Targets and Effects |
COX-2 inhibitor |
Pathways |
Apoptosis |
Physical |
Appearance |
Solid powder |
Purity |
>98% (or refer to the Certificate of Analysis) |
Shipping Condition |
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition |
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
Shelf Life |
>2 years if stored properly |