Fotemustine
Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
| Chemical | |
|---|---|
| CAS Num | 92118-27-9 |
| Chemical Formula | C9H19ClN3O5P |
| Molecular Weight | 315.69 |
| IUPAC Chemical Name | diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate |
| Exact Mass | 315.07508 |
| Elemental Analysis | C, 34.24; H, 6.07; Cl, 11.23; N, 13.31; O, 25.34; P, 9.81 |
| Synonym | Foreign brand name |
| Solubility | Soluble in DMSO, not in water |
| SMILES Code | CC(P(OCC)(OCC)=O)NC(N(CCCl)N=O)=O |
| Biological | |
| Targets and Effects | N/A |
| Pathways | alkylating agent |
| Physical | |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Shelf Life | >2 years if stored properly |
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